Moderna’s Experimental Flu Vaccine Outperforms Marketed Vaccine in Phase 3 Study
In a groundbreaking development, Moderna’s experimental mRNA-based seasonal flu vaccine has exhibited a stronger immune response against four strains of the flu virus in comparison to a currently available vaccine, according to findings from a Phase 3 study. The vaccine, known as mRNA-1010, was pitted against GSK’s Fluarix in the study, with mRNA-1010 proving to be more effective.
With mRNA technology gaining increasing recognition for its potential in bolstering the efficacy of seasonal flu vaccines, Moderna finds itself in a fierce race against competitor Pfizer. The aim is to bring mRNA technology to the forefront of flu vaccines, thereby enhancing their effectiveness against the prevailing strains of the flu virus.
Moreover, Moderna intends to consolidate its efforts by combining mRNA shots for Covid-19, flu, and RSV if subsequent studies confirm their safety and efficiency. Specifically, the pharmaceutical giant expects a decision from the FDA regarding its mRNA vaccine for RSV in adults aged 60 and above by April.
The success of Moderna’s mRNA platform has been underscored in phase 3 trials across various respiratory disease programs, including Covid-19 and RSV. These positive results have further fueled the company’s determination to leverage the potential of mRNA-based vaccines in combating viral infections.
To enable efficacy against both A and B strains of the flu virus, the experimental flu vaccine underwent reformulation. The study also emphasized assessing the immune response rather than its ability to shield against flu disease, indicating a strong emphasis on a robust defense mechanism.
Safety findings relating to the mRNA flu vaccine were consistent with previous studies. Common reactions included muscle pain, headache, fatigue, pain, and swelling. These typical responses reaffirm the vaccine’s comparability to existing vaccines in terms of safety and tolerance.
Notably, Moderna halted another phase 3 study due to insufficient cases that could provide efficacy data. This move was prompted by the positive results obtained from the initial phase 3 study, signifying a groundbreaking advancement in the realm of flu vaccines.
As Moderna continues to innovate and pioneer the use of mRNA technology, the possibility of a more effective and comprehensive flu vaccine seems increasingly promising. With ongoing research and development, the fight against seasonal flu may be approaching a turning point, holding potential implications for global public health.
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